The airline said it had more than 3,000 first aid trained and security cleared staff up and down the country ready to assist.
"Furloughed crew have an ideal skill set to be able to assist in the effort to provide much needed inoculation support to the NHS in rolling out the Covid-19 vaccine," said easyJet.
Those fast-tracked to assist will undergo online training followed by on-site immunisation training to become full-qualified vaccinators.
Last year, easyJet crew came forward to support the NHS Nightingale hospitals and volunteer as NHS responders.
