Twice-weekly flights, flying Tuesdays and Fridays, will get under way on 1 November and will continue through to 29 April 2020.
Fares lead in from £39.99 one way, and include 8kg hand baggage.
Marrakech is situated about 75 miles inland from the Atlantic coast; it is within striking distance of capital Rabat, the city of Casablanca and coastal resort of Agadir.
It is famed for having Morocco’s largest traditional souk (market) comprising more than a dozen separate areas selling local produce to modern goods.
Cook is offering three nights all-inclusive at the four-star Sentido Kenzi Manara in Marrakech from £284pp, which include return flights from Gatwick with Thomas Cook Airlines.
Packages are available for the duration of the seasonal route through 29 April, with prices based on two adults sharing.
Bookable extras include transfers and additional luggage.
A Cook spokesperson said the packages would be available to the trade imminently.
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