The service will get under way on January 9. Flights will operate on Wednesdays and Saturdays.
The route will be operated by Boeing 737-800 aircraft. Return fares will lead in from £149pp, including taxes and fees.
Turkish Airlines general manager Celal Baykal said: “We’ve introduced this new Turkish Airlines route in direct response to the rise in passengers looking to travel to this destination.
“This is the first time we have operated a direct flight out of London Gatwick to Ankara and see this as part of our continued growth plans.”