The talk show host and media mogul will christen the vessel in a private ceremony to take place on an undisclosed date.
The vessel, the line’s second Pinnacle-class ship, is set to be delivered in December 2018 and is currently under construction at Fincantieri’s Marghera shipyard in Italy.
Winfrey will sail on a three-day "Girls’ Getaway" itinerary on January 30, 2019 from Fort Lauderdale.
She will be joined by editorial staff from O, The Oprah Magazine, including editor-at-large Gayle King.
Passengers will be able to attend one of three live "Conversations with Oprah" sessions onboard.