The twice-weekly route will operate on Wednesdays and Sundays from October 28 with prices leading in at £38.99 one way
Paphos takes the number of routes operated by Ryanair from Liverpool to 33 and follows last month’s news that Ryanair will recommence flights to Shannon from Liverpool for summer 2018.
Liverpool John Lennon airport director of aviation development Paul Winfield said: “We are delighted to see Ryanair take the opportunity to add flights to Paphos from Liverpool which is on one of the largest unserved markets from here.
"This new service will allow passengers from across the North West to fly to Paphos from Liverpool John Lennon Airport and enjoy a best in class passenger experience.”