Tui chief Fritz Joussen has said the operator is "preparing intensively" to relaunch in Spain.
Joussen has welcomed Spanish prime minister Pedro Sanchez’s pledge to reopen the country to foreign tourists from 1 July.
"Now we can plan holidays for Majorca, the Spanish mainland and the Canary Islands and make our customers an offer," said Joussen.
Joussen added it the move would give holidaymakers certainty Spain would be open for travel during the summer school holidays.
"This is a good signal for many families, but also for Tui as a tour operator and the travel agencies that advise customers on their holiday decisions," he continued.
"After Greece, Cyprus, Croatia and Bulgaria, Spain has now also provided clarity for the start of the holiday season."