There are no direct commercial flights from the UK or Ireland, making the Johannesburg and Cape Town routes perfect for St Helena stays of less than a week, as part of a twin-centre trip with South Africa. For example:
Three-night itinerary
On Saturday fly from Cape Town to St Helena, with return on Tuesday flying from St Helena to Johannesburg.
Four-night itinerary
On Tuesday fly from Johannesburg to St Helena, returning on Saturday flying from St Helena to Cape Town.
These itineraries can be extended up to 10 or 11 days for longer stays.
| Airline | Origin | Destination | Frequency | Seats |
| Airlink | Johannesburg | St Helena Airport | Weekly (year-round) | 96 |
| Airlink | Cape Town | St Helena Airport | Weekly (peak season Dec-March) | 96 |