It comes after the airline launched its inaugural transatlantic service from Manchester to Barbados in October last year.
The carrier will offer a three-times weekly service, flying direct from Manchester from 2 November until 30 April, every Wednesday, Friday and Sunday. Fares start from £245pp.
Susanne Carberry, Aer Lingus chief customer officer, said: "We’re excited to be restarting flights to the Caribbean again this November direct from Manchester, taking advantage of customer demand for winter sun.
"The service which was introduced just over a year ago has been successful, leading to the route recommencing this November again."
