Sailing between 20 February and 21 June 2022, the vessel will visit 32 ports in 12 countries, including Norway, Spain and Portugal.
The programme also includes six overnight port calls and three late-evening departures.
A call in Amsterdam on a four-night short break brings an opportunity to explore the city’s canals by night while other highlights include Genoa, Ibiza, Manzanillo, Grand Turk and San Francisco.
Cunard president Simon Palethorpe said the new programme has "something for everyone".