Rome-bound services will take off from Birmingham, Leeds Bradford, Manchester, Newcastle and London Stansted between 1 and 5 February 2024, in time for the Italy v England match on 3 February.
Four additional flights will depart from Birmingham on 1, 2, 4, 5 February, while two extra services will leave from Leeds on 2 and 5 February.
Those flying from Manchester and Newcastle will take advantage of two additional departures on 2 and 5 February, while Londoners will have four additional services between Thursday and Monday.
Scottish supporters will be able to attend their team’s clash with Italy on 9 March with two additional flights departing from Glasgow on 8 and 11 March.
Independent travel agents will also be able to make bookings through Jet2CityBreaks, which will include flights, a 22kg luggage allowance and accommodation.
Jet2 chief Steve Heapy said the operator had already seen “a strong demand.”
“We have a superb programme on sale to Rome for the 2024 Six Nations and based on previous demand through the trade, we expect it to sell very well indeed,” Heapy added.