The budget carrier has put 60,000 seats on sale from Norwich across three twice-weekly routes to Alicante, Faro and Malta, which will take off in the spring.
Ryanair said the launch would create more choice for holidaymakers in Norfolk and lay down a challenge to "sky high" fares at the airport.
In addition, Ryanair said the new base would drive inbound tourism to the region and create more than 60 new jobs locally. Promotional fares lead in from £29.99pp.
