The new service, which will take off in October 2027, is the culmination of Qantas's Project Sunrise mission, which started in 2017 when it challenged Airbus and Boeing to come up with aircraft that could fly the route non-stop.
Qantas has served the route since 1947, when it originally took four days and included seven stops between Australia and the UK.
The new service will be the first non-stop connection between Australia's east coast and the UK, shaving up to four hours off current journey times and removing the need for passengers to transit through hubs such as Singapore or Perth.