The Irish flag carrier’s three-times-weekly Vegas service will take off on 25 October.
It will operate the route on Tuesdays, Thursdays and Saturdays using an Airbus A330-300 aircraft.
Flights will operate through to 29 April 2025, taking in the Easter holidays.
"Aer Lingus is bringing this iconic destination to customers seeking an escape to the winter sun," said the airline’s chief executive Lynne Embleton.
Steve Hill, president and chief executive of the Las Vegas Convention and Visitors Authority, said more than 52,000 Irish visitors travelled to the city last year.
"This direct, non-stop service from Dublin will undoubtedly be motivation for Irish travellers and visitors throughout the UK and Europe to discover everything Las Vegas has to offer," he added.
Vegas passengers connecting from the UK via Dublin can take advantage of US immigration pre-clearance, allowing them to arrive like domestic passengers and avoid lengthy queues.
Return fares lead in from £569pp including taxes and charges.
Flights will depart Dublin at 3.20pm, arriving in Vegas at 5.50pm – a flight time of approximately 10 hours. Returns will depart Vegas at 7.35pm, arriving in Dublin at 1.30pm (+1).
