The 280-passenger vessel is currently under construction at the Concordia Damen shipyard in Rotterdam.
Sena, which is Arabic for "beauty", will depart on its inaugural seven-night voyage from Cologne along the northern Rhine on 21 May 2022, calling at Amsterdam, Rotterdam, Dordrecht and Antwerp.
It will be the largest ship in A-Rosa’s fleet, at 135m long and 17.7m wide, featuring a hybrid propulsion system which combines a diesel and electric engine.
A-Rosa managing director Lucia Rowe said Sena will "lead the way" in sustainable river cruising.
