It is the second time Advantage has had to push back the event, due to be held at the Savoy Palace Hotel, owing to the Covid crisis.
The event will now be held from 29 April to 2 May 2022 at the same venue.
"While we are very disappointed we have to cancel our event for the second year in a row, we feel the current uncertainties around vaccine passports, testing requirements and restrictions means we simply do not have a choice," said Advantage in a statement.
"We remain committed to bringing back our event in 2022 at the same location with top-quality content, fantastic speakers and lots of great networking opportunities for our delegates."
Nuno Vale, executive director of the Madeira Promotion Bureau, added: "Although we are disappointed that the current pandemic does not allow us to receive the Advantage conference this year, Madeira will be welcoming all the Advantage Travel Partnership members and partners with open arms next year.
"We believe this will be even a better opportunity to explore brand new avenues in our partnership and work together for a brighter future for the British travel industry and Madeira islands touristic destination."
Advantage added it would be announcing a series of events across the UK from July through to November. "We look forward to getting back on the road and catching up with members and suppliers soon. We remain focused on providing daily support, advice and expertise to help our members."