Flight EI 35, operated by an Airbus A330, is the third route launched by the airline as part of its new services from the UK airport direct to the US and the Caribbean.
Aer Lingus also launched flights from Manchester to Barbados on 20 October and to New York on 1 December.
The four-times weekly service departs at 11am every Monday, Tuesday, Thursday and Saturday. Fares start from £209 each way.