Air Malta will restart UK flight operations in mid-July.
Heathrow services will get under way from 15 July, the carrier has confirmed.
Manchester flights will follow August, it said on Wednesday (17 June).
It follows a three-month closure of Malta’s international airport to commercial operations owing to the coronavirus pandemic.
Air Malta’s summer schedule will launch on 1 July, and will eventually connect the Mediterranean island nation with 22 European destinations.
From 1 July, flights will operate to Berlin, Catania, Dusseldorf, Frankfurt, Geneva, Lyon, Marseille, Munich, Prague, Rome, Vienna and Zurich.
Amsterdam, Brussels, Heathrow, Lisbon, Madrid, Milan, Palermo, Paris Charles De Gaulle and Paris Orly will follow from 15 July.
Madrid is a new addition to Air Malta’s route network, restoring a link with the Spanish capital for the first time in more than a decade.
Air Malta’s planned Luxembourg service, meanwhile, has been transferred to Brussels.
Fares lead in from €39 one-way.
The airline will detail its new health and safety protocols in the coming days.