British Airways is pulling its Gatwick-Fort Lauderdale service in September for commercial reasons.
Then airline has been operating the route four times a week with prices leading in at £299 return in economy.
However, the airline has now confirmed the last flight would be run on 9 September, adding that the region would still be well served by the airline.
A spokesperson added: “We regularly review our schedule to ensure that we are flying to destinations that are popular with our customers.
“Through our partnership with American Airlines, we already fly 28 times a week to nearby Miami airport and from October 2019 our customers will have even more flights to choose from on this route.”