The airline’s regional general manager Europe James Ginns said the decision to up the five-times weekly service from the start of December had been made in response to strengthening northern economic activity.
He added flights would be operated using an Airbus A350 and once in Hong Kong, passengers can access connections to a further 190 destinations.
Ginns said: “Boosting our Manchester flights into a daily service highlights the popularity of the route and the global importance of the Northern Powerhouse.
“We are delighted to be part of the journey in forging further links between the North West, Asia and beyond.
“The Northern Powerhouse and Hong Kong share a parallel focus on science, innovation, technology and the arts; both dynamic cities are built on hard-working, business-savvy communities with a huge appetite for arts and culture.
“We would like to take this opportunity to thank those living in the region who have helped to make the route such a success.”
Manchester airport commercial director Stephen Turner added: “The route provides easy access for leisure and business travellers, plus unlocks a host of economic opportunities for both destinations.
“We are delighted how popular the route has been in its three years of operation, and look forward to working with the airline as it grows from the UK’s global gateway in the North.”