Cameron, who left office in July in the wake of the EU Referendum, will speak to delegates at the organisation’s Global Summit, which is due to be held in Bangkok on April 26-27.
The ex-Conservative politician will discuss geopolitical issues currently facing the travel sector as part of the main conference’s main theme "Transforming our World".
David Scowsill, WTTC president and chief executive, said: “I am delighted that Mr Cameron will join us at our Global Summit this year.
"His international stature and first-hand experience of leadership on the world stage will bring extremely valuable insights.”