The up to three-times-weekly winter route will operate until 24 March 2023. Flights will operate on Wednesdays, Fridays and Sundays, with fares from £17.99pp.
Ali Gayward, easyJet’s UK country manager, said the route would provide more choice for business and leisure travellers.
"We continue to further strengthen our network in Belfast, having recently added services to Gatwick, Liverpool, and Glasgow from Belfast City, which are already proving very popular with our customers," said Gayward.
Ellie McGimpsey, Belfast City aviation development manager, added: "We are confident Bristol will prove popular with business and leisure passengers alike, with the convenient flight times and three-times-weekly service giving travellers a hassle-free link to the south-west of England.
"This new route adds to easyJet’s portfolio at Belfast City, with services to Gatwick and Liverpool already operational, and flights to Glasgow set to commence in October.”