From 4 May, the 3,660-guest Royal-class vessel will offer 13 new voyages ranging from four to 14 nights.
Enchanted joined the Princess fleet in November 2021 and is currently completing its inaugural Caribbean season before heading to Europe in April. It will then join sister ship Sky Princess as well as Emerald Princess and Island Princess to sail out of Southampton later this year.
New itineraries include short cruises and longer voyages to the Canary Islands, Mediterranean, Scandinavia, Norway and Iceland.
All-inclusive balcony fares start from £499pp for a five-night cruise to Belgium, Channel Islands and the Netherlands, departing 15 May.
Tony Roberts, vice president of Princess Cruises UK and Europe, said the decision to base Enchanted in Southampton was "driven by the fantastic response" from UK travel agents on having two Royal-class ships sailing out of the port in 2021.
"We’ve been extremely encouraged by demand for Princess Cruises’ 2022 sailings, with UK bookings already exceeding our full year 2019 result," he added.
"This could not have been achieved without our UK travel agent partners. Having two of our newest ships based in Southampton this summer is testament to their continued support."
Enchanted’s new cruises will go on sale on 23 March at 8am.
