The new route will be operated by a 78-seat Bombardier Q400 aircraft, starting April 21, and will mark the relaunch of Flybe’s base on the island.
One-way fares lead in from £36.99 and are available to book now for travel through October 26.
The launch will be the first time since March 2002 the island has had a direct connection to London’s largest airport, offering onwards connections worldwide.
Flights will depart the Isle of Man at 1.50pm, arriving at Heathrow at 3.10pm. Return flights will depart Heathrow at 5.05pm, arriving on the Isle of Man 6.25pm.
Roy Kinnear, Flybe chief commercial officer, said: “We are naturally delighted to provide the Isle of Man with renewed connectivity to the capital and onwards to the multiple long-haul destinations available via Heathrow as we start our operations again from the Isle of Man. We look forward to welcoming many new passengers on board this direct service.”
Isle of Man Director of Ports Ann Reynolds added: “This great news is a welcome addition and is a route that our diverse business economy has been seeking.”
Flybe’s summer 2019 schedule will feature five routes to and from the Isle of Man - Heathrow, Birmingham, Liverpool, Manchester and briefly Geneva, with flights to the Swiss business hub carrying over from the airline’s winter programme until April 13.
