From 30 October, the carrier will fly to twelve destinations with additional routes and frequency from Heathrow to Newquay, Birmingham to Belfast City, Belfast City to East Midlands and Southampton to Glasgow.
It will also continue to operate international flights to Amsterdam from Belfast City, Birmingham, East Midlands and Heathrow, due to demand.
The airline will be adding additional flights throughout the winter and into next summer as it expands its fleet with new Co2-efficient De Havilland Canada Dash 8-400 (Q400) aircraft.
Flights lead in from £34.99 one way.
Flybe chief executive Dave Pflieger, said: "After a successful 2022 launch and summer season, we are excited to announce our new winter schedule, which further enhances affordable connectivity across UK regions, as well as Europe via our popular flights to Amsterdam."
