The Pinnacle Class vessel will sail a series of 23 seven-day cruises to the California coast and Mexico until 3 April, 2022.
HAL president Gus Antorcha said the company is "thrilled" to return to cruising from San Diego.
"Our guests are eager to be back onboard and our team members look forward to reconnecting with them and providing a memorable vacation," he added. "We’re ready for a successful season of cruising."
Zuiderdam will also sail roundtrip cruises from San Diego on longer Mexico itineraries, as well as a month-long voyage to Tahiti and Panama Canal departures.
