The airline and operator are looking to hire 100 new staff at the airport after strong demand for flights and package holidays inspired the firms to launch a "significantly expanded" programme from Bristol for summer 2023.
The companies are looking to recruit individuals to fill cabin crew, ground operations, flight deck and engineering positions.
The expansion includes two new destinations for summer 2023 from Bristol – Malaga and Chania (Crete) – bringing the airline and operator’s programme from the airport to 32 sun and city destinations.
A seventh-based aircraft will come into operation at the base to support the expansion.
Steve Heapy, chief executive of Jet2.com and Jet2holidays, said: "We are extremely excited about our third summer at Bristol airport, which will be our busiest and biggest yet.
"Since launching flights and holidays in 2021, the response from customers and independent travel agents across the South West and South Wales has been enormous and this has enabled us to enjoy the growth we have seen."