The airline and operator will offer around 120 outbound services to Iceland from across 10 UK bases.
It will fly twice-weekly scheduled services to Iceland from Birmingham and Manchester airports from 29 September until 21 November in 2022, and from 9 February to 24 April in 2023.
In addition, the company will also operate a series of dedicated flights and trips to Iceland from Bristol for the first time, in addition to flights from Belfast, Edinburgh, East Midlands, Glasgow, Leeds Bradford, Manchester, Newcastle and Stansted.
Steve Heapy, chief executive of Jet2.com and Jet2holidays, said Iceland has continued to see "strong demand".