Flights will get under way on 20 December 2021 and will operate through to 16 April 2022.
Lyon opens up a range of popular French resorts, including Tignes, Chamonix, La Plagne, Les Deux Alps and Alpe d’Huez.
It grows Jet2’s 2021/22 ski flight programme to eight routes; Barcelona (Andorra), Chambery, Geneva, Grenoble, Innsbruck, Lyon, Salzburg and Turin.
Steve Heapy, Jet2.com and Jet2holidays chief executive, said: “After missing out in winter 2020/21, skiers and snowboarders are well and truly looking to hit the slopes again.