Flights will get under way on 20 December 2021 and will operate through to 16 April 2022.
Lyon opens up a range of popular French resorts, including Tignes, Chamonix, La Plagne, Les Deux Alps and Alpe d’Huez.
It grows Jet2’s 2021/22 ski flight programme to eight routes; Barcelona (Andorra), Chambery, Geneva, Grenoble, Innsbruck, Lyon, Salzburg and Turin.
Steve Heapy, Jet2.com and Jet2holidays chief executive, said: “After missing out in winter 2020/21, skiers and snowboarders are well and truly looking to hit the slopes again.
"We have seen great demand on the back of that, so we have taken the decision to provide customers with even more choice through the launch of ski flights to Lyon."
