The London City service will launch on 19 April, initially offering a daily flight (except Saturdays) before increasing to two flights each weekday from 3 May.
The new schedule will offer day-return capability in each direction, plus a flight in each direction on Sunday evenings.
A daily service to Heathrow will commence from 3 May. Both routes will be flown under Loganair’s codeshare agreement with British Airways, and tickets for the new flights will go on sale next week.
Loganair’s chief executive Jonathan Hinkles said the flights will offer "excellent connectivity" to London.
"We’re absolutely delighted that the Isle of Man’s airline is restoring island-based connectivity to London – serving not just one but two major airports," he added.
"Our conveniently timed flights to London City will offer excellent connectivity to the heart of London for both business and leisure travellers."
