Aeroitalia will link the Essex airport with Bergamo, 28 miles from Milan, from 25 March. The carrier will fly six times a week, with one-way fares from €79.99.
Bergamo airport, which was popularised by Ryanair, offers a bus service every 10 minutes to Milan, Italy’s fashion hub.
John Upton, Southend airport chief executive, said: “We are delighted to announce this new and exciting collaboration with Aeroitalia, the second largest Italian airline in Italy, bringing near-daily flights to Milan Bergamo.