MSC Virtuosa will sail its inaugural season, featuring an initial six mini-cruises with a stop in Portland, Dorset, from Southampton, starting 20 May.
The four-night sailings have been designed as short getaways for couples and/or friends, taking in the Jurassic Coast and featuring a day out on the beach as part of a "protected excursion".
These will be followed from 12 June by a series of seven-night sailings from Southampton, with embarkation from Liverpool and Greenock, as well as a stop in Portland.