The move comes "given the significant, positive progress in the public health environment" as the line looks to align itself with other global travel organisations.
"Health and safety are always our first priority; in fact, we were the health and safety leaders from the very start of the pandemic," said Harry Sommer, NCL president and chief executive officer.
"Many travellers have been patiently waiting to take their long-awaited vacation at sea and we cannot wait to celebrate their return."
With the easing of its health and safety protocols, NCL will continue to follow the travel guidelines as required by the destinations it visits.