The line will operate three seven-night ex-Southampton sailings specifically aimed at families whose children go to schools in different countries within the UK.
The voyages depart on 18 October, 25 October and 1 November 2025. Each sailing covers a different October half-term either in Scotland, Northern Ireland and England.
A P&O Cruises spokesperson said: “Consequently, there will be a much larger number of holidays departing during this period.”
P&O Cruises sales director Ruth Venn said: “We’ve tried to put three consecutive sailings to cover each of three half terms. It’s great to have broad appeal.”