Mission Control, which is an immersive experience combining an escape game with multimedia simulation and a live-action story, offers two one-hour experiences: an adventure suitable for all ages and an adventure designed for adults.
Set onboard fictional submarine Arvia II, guests will board in groups of up to 10 to form a team under the guidance of Dr Melissa Ryan, a virtual character who will guide passengers through their mission.
The 3D surroundings will take guests into ocean canyons, encountering sunken cities and underwater creatures.
P&O Cruises president Paul Ludlow said: "Our technology partner specialises in things that have never been done before, so boarding Arvia II is guaranteed to wow our guests and be like being in the biggest blockbuster movie."
Arvia will depart on its 14-night maiden Canary Islands voyage from Southampton on 9 December 2022. Prices start from £1,299pp.
