Venn, previously the line’s senior business manager for strategic partnerships, will be responsible for travel agent sales revenue and trade engagement, including training, events, communications, and sales support.
Priorities for the coming months will include growing existing travel agent partnerships and attracting new ones, as the company takes on new capacity with the introduction of Arvia in December.
P&O Cruises vice president of brand, marketing and sales, Robert Scott, said Venn has an "infectious passion" for cruising.
"I am delighted to promote Ruth into this position and have every confidence in her ability to take on this role with relish," he added.
"Over the past two years agents have had to communicate so many changes and new protocols to guests it has been relentless."
Scott said 2022 will be a "vital year" for P&O and "there has never been a more important time to prove to the trade just how important they are".
"As our full fleet returns to service in the spring and we can, at last, see some relief from Covid, the appetite for holidays is stronger than ever," he continued.