The budget carrier will base two aircraft in the north-east, allowing it to grow its Newcastle route network to 19.
New additions include Chania, Fuerteventura, Gran Canaria, Ibiza, Krakow, Menorca, Milan, Paphos, Riga and Zadar.
In total, Ryanair says it will operate more than 130 flights a week from Newcastle during the summer peak, 40 more than it did in summer 2019.
It added the move represented an investment amount to around £150 million, one that would create 60 direct new jobs.
