The escorting tourist specialist had planned to relaunch tours to the country in 2020, only for its plans to be placed on hold due to the pandemic.
A new eight-day Treasures of Egypt tour will take in Cairo, the Pyramids, the Nile, Luxor and Aswan.
Prices lead in from £2,224pp with 2023/24 departures getting under way in September, including flights, accommodation and meals. Group sizes are limited to 35.
“We’re so excited Travelsphere is returning to Egypt, which was always one of our most popular destinations," said Travelsphere sales director Sarah Weetman.