The Mediterranean is second-most popular, with the Caribbean third and Canada fourth. Bookings made by UK cruise guests to the US have grown by 12% compared to pre-pandemic levels, according to Cruise.co.uk.
The cruise specialist agency said there had also been an increase in the length of time that people are booking overseas cruises. The proportion of guests sailing 14-20 night itineraries has risen from 32% to 35% compared to 2019, and the number of guests sailing 21 nights or more has gone up from 6% to 9%.
Meanwhile, the percentage of travellers booking their sailings from the UK to overseas destinations has also increased from 27% to 37%.
January and February remain the most popular months for UK holidaymakers to travel on an international cruise.
Tony Andrews, deputy managing director of cruise.co.uk, said the US has always been a "go-to port of call" for overseas cruise guests.
"The fantastic variety of holiday options on offer, including a wide range of ships and itineraries, means the US continues to appeal to both seasoned cruisers and first-time passengers alike," he added.
"It’s also interesting to see a slight shift in the proportion of people booking extended sailings. This may well be a sign they’re looking to get away for longer, to help make up for the holidays they’ve missed during the past 18 months."