Flights operate on Sundays, Wednesdays and Fridays on the Airbus A350-1000, the carrier’s newest aircraft. Prices for return economy flights start from £856 per person.
The service compliments the airline’s existing daily flights from Heathrow to Las Vegas, which continues to be “a key destination” for British travellers, Virgin Atlantic said.
The reintroduced service is the fourth route Virgin Atlantic operates from Manchester to the US, building on established services of Orlando, New York, and Atlanta.
Dom Kennedy, senior vice-president at Virgin Atlantic Holidays, said: “We’re thrilled to be re-introducing our Manchester to Las Vegas service.