The Escape the Everyday campaign aims to support cities, city attractions and regional gateways hit hard by the lack of international visitors and their spending.
VisitEngland estimates the loss in domestic tourism spending in England in 2020 and 2021 combined to be more than £77 billion.
The campaign’s focus is on 18 cities including Birmingham, Coventry, Exeter, Leeds, Norwich, Plymouth, Portsmouth and Sheffield as well as more high-profile destinations.
VisitEngland director Andrew Stokes said: “Whether you are looking to experience England’s rich history, stay at an eco-friendly retreat, or discover hidden foodie gems, our cities have attractions, tours and experiences to suit all interests.”
A digital, partner-led campaign runs to 31 March. Local businesses will be able to join in using QR codes on window stickers to help visitors discover what each city has to offer.