The airline, a joint venture of Tata group and Singapore Airlines, used a new Boeing 787-9 Dreamliner for the service to the UK’s hub airport.
The Heathrow-Delhi service will operate three times per week on Monday, Wednesday and Friday in each direction from 28 August to 24 October as part of a bilateral “transport bubble” between the UK and India.
Leslie Thng, Vistara’s chief executive, said: “Though not regular scheduled flights, we are excited about starting operations to our first long-haul destination.