The budget carrier opened its Cardiff base on Friday (8 April). Wizz will offer nine routes from the Welsh capital.
Flights to Tenerife and Lanzarote took off on Friday, followed by Alicante, Faro and Palma on Saturday and Larnaca on Sunday.
Wizz’s Cardiff-Crete (Heraklion) route will get under way on Wednesday (13 April). Corfu flights will start on 16 June and Sharm El Sheikh on 1 November.
Flights will be operated by Airbus A321 aircraft, the wings of which are made in Wales.
"It marks a real turning point for the airport in its post-Covid-19 revival plans,” said Cardiff airport chief executive Spencer Birns.
“Our customers in Wales have been asking for a more cost-effective choice for many years. What makes this launch so exciting is that Wizz Air is an ultra-low cost airline that will help build competition and offer improved choice to people living in Wales and the south west."
The new base will create more than 40 new direct jobs and in excess of 250 indirect, said Binns, "supporting industries such as hospitality, transportation, aerospace, and tourism."
Cardiff is Wizz’s fourth UK base; it also has aircraft based at Gatwick, Luton and Doncaster-Sheffield.
