From 13 December the carrier will operate two flights a week to Bydgoszcz and Lodz.
Wizz describes Bydgoszcz as “a storybook city on the water", while the third-largest city in Poland, Lodz, is known for its street art and Jewish heritage.
Marion Geoffroy, Wizz Air’s UK managing director, said: “Our continued growth at Luton reaffirms our commitment to offering passengers ultra-low fares to a variety of exciting destinations. We look forward to welcoming passengers onboard to experience our high-quality service and young and efficient aircraft.”