The carrier will operate up to 86 flights a week from Newcastle – almost double the number it offered last year – with the programme stretching to around 800,000 seats this summer.
Among the 22 new routes taking off from Newcastle this week are Antalya, Corfu, Dalaman, Enfidha, Faro, Lisbon, Malta, Nice, Prague, Reus, Rhodes, Rome, Sharm-El-Sheikh and Tenerife.
Chief executive Kenton Jarvis said the new base would strengthen connectivity in northeast England, southern Scotland, north Yorkshire and Cumbria.