Globus said his decision follows "a change in personal circumstances" and will allow him to "focus on his wellbeing and plan for his next chapter".
Recruitment for Shipman's successor will start soon, said Globus, with Managing Director Lesley Taylor stepping in to support the group's UK and Ireland sales team until a replacement is found.
Shipman's travel industry CV includes spells at Classic Collection, Sani/Ikos Group, and G Touring brands Travelsphere and Just You.
Globus said Shipman had been "instrumental" in growing and strengthening the trade team across Cosmos Tours, Globus Journeys and Avalon Waterways.