The store – which is located at the Charter Walk Shopping Centre and will be open seven days a week – had its grand opening on Friday 19 September. It does not replace an existing travel agency.
Branch manager Natalie Lowcock – who has been with Hays Travel for three years, having previously managed the Colne branch – will lead a team of eight.
She returns to Burnley 27 years after starting her travel career in the Lancashire town with Going Places.
She said: “We enjoyed a very successful opening weekend.
“There have been a lot of visitors so far and there has been a fantastic atmosphere over the last few days.
“We were delighted to welcome some of our suppliers on Friday [including P&O Cruises, Ocean Florida and Flexible Autos], and Barbie also made an appearance on Saturday to help promote our £500 giveaway competition!”
Jane Schumm, Hays Travel’s retail director, said: “Burnley has been on our radar for a long time and our colleagues had a brilliant weekend meeting the community who have been very welcoming.”