The operator claims it will be the only UK package holiday provider to fly direct to the archipelago in the Indian Ocean. Tui will operate the route twice-a-week on Wednesdays and Sundays from 3 November 2027 to 22 March 2028.
Tui said the decision to start flying to Zanzibar direct came in response to "growing demand for alternative long-haul winter sun destinations" and would make it most accessible than ever to UK travellers.
"It also offers a more affordable alternative to Indian Ocean favourites like the Maldives and Mauritius, giving it growing appeal among Brits looking for great value long-haul options," said Tui.