Flights to Orlando and Newark from Dublin will resume once restrictions are lifted, with connections from UK airports.
Dublin to Orlando will operate three times per week from 27 November, with fares starting from €169 each way.
Dublin to Newark will operate four times per week, increasing to daily from 1 December, with fares from €149 each way.
Direct flights from Dublin will also resume to Geneva and Prague from 15 October and to Frankfurt and Zurich from 8 November. In addition, the Knock to Gatwick route will resume for the festive season on 18 December.
Susanne Carberry, the airline’s chief customer officer, said: “We are delighted to announce a significant restart to a number of our favourite routes in North America and Europe and reconnecting friends, families and businesses once again.
“We are also excited to be able to connect Irish customers with European cities of Prague, Geneva, Zurich and Frankfurt - destinations which are particularly popular in winter for their Christmas markets and the upcoming ski season.”