The route will be operated by Air Canada rouge, its leisure carrier, and will start next summer.
The new service between the two cities will fly three times per week from June 14 to September 25, 2016.
It will be operated by 280-seat wide-body Boeing 767-300ER offering premium and economy cabins.
“We are pleased to offer our Scottish customers even greater access to Toronto and beyond with direct flights from Glasgow next summer,” said Margaret Skinner, Air Canada’s director, sales - Europe.
“These additional flights complement our existing summer service from Edinburgh, offering convenient connections to destinations across North, Central and South America as well as the Caribbean through our Toronto hub.”
Francois Bourienne, commercial director at Glasgow airport, said: “The decision by Air Canada rouge to introduce a direct service between Glasgow and its hub in Toronto is fantastic news for the airport and for Scotland."