The daily service will fly between March 31 and October 26, complementing partner British Airways’ existing Heathrow-Phoenix route. It will be operated by a Boeing 777-200 aircraft.
American has also added a daily Philly-Edinburgh service, flying April 2 to October 26, and a daily Dallas/Fort Worth-Dublin service, flying June 6 to September 28.
However, citing fuel prices and competition, American will trim four “unprofitable” seasonal dailies serving the UK and Ireland.
Its long-standing Chicago O’Hare-Manchester service will cease on September 3, followed by its Philly-Glasgow service on September 29.
Its Dublin and Edinburgh services from New York JFK will end on October 27.
The new flights will go on sale on Monday (August 27).
Vasu Raja, American’s vice-president network and schedule planning, hailed its partnership with BA, adding the two airlines’ “extensive networks” each side of the Atlantic would enable further long-haul expansion.